[2005/03/11] Bacterial Engineering On Par With Higher Life
Bacterial Engineering On Par With Higher Life
03/11/2005 Bacteria aren¡¯t the simple life-forms microbiologists
used to envision, writes Zemer Gitai in Cell.1
Recent advances have demonstrated that
bacterial cells have an exquisitely organized and dynamic
subcellular architecture. Like their eukaryotic
counterparts, bacteria employ a full complement of cytoskeletal
proteins, localize proteins and DNA to specific
subcellular addresses at specific times, and use
intercellular signaling to coordinate multicellular
events. The striking conceptual and molecular similarities between
prokaryotic and eukaryotic cell biology thus make bacteria powerful
model systems for studying fundamental cellular questions.
(Emphasis added in all quotes.)
This is different from the
traditional picture of bacteria, he elaborates:
This traditional perspective [of
bacteria as fundamentally different from eukaryotes (i.e., simpler]
changed significantly in the past decade with dramatic advances
in our understanding of bacterial cell biology. Work in multiple
species has demonstrated that bacteria are actually highly ordered
and dynamic cells. Much like their eukaryotic
counterparts, bacterial cells are capable of polarizing,
differentiating into different cell types, and signaling
to each other to coordinate multicellular actions. The more
recent surprises come from advances in fluorescence microscopy,
demonstrating that bacterial cells exhibit a high level of
intracellular organization. Bacteria dynamically localize
proteins, DNA, and lipids to reproducible addresses within
the cell and use this dynamic organization to tightly regulate
complex cellular events in both space and time.
Gitai provides detail on the following examples: (1)
Bacteria have homologs of the eukaryotic cytoskeleton, (2) bacterial cells
are subcellularly organized (i.e., are not lacking organelles or a
nucleus-like function), (3) several mechanisms underlie bacterial
subcellular organization, and (4) bacteria are able to engage in
multicellular activities. ¡°Bacteria are wondrously
diverse and resourceful, occupying virtually every environmental niche
imaginable,¡± he writes in conclusion.
1Zemer Gitai, ¡°The New Bacterial Cell Biology:
Moving Parts and Subcellular Architecture,¡± Cell,
Volume 120, Issue 5, 11 March 2005, Pages 577-586,
doi:10.1016/j.cell.2005.02.026.
Sadly, Gitai assumes evolution in
various places, but not with evidence: only with inference, in spite of
the evidence. For example, ¡°If systems are similar due to
convergent evolution, they can point us toward nature¡¯s
optimal solution to a problem, whereas, if they differ due to
divergent evolution, they can identify the basic rules
that have remained intact.¡± Those are pretty big ifs. What
if they are both due to intelligent design? He would never think
of asking the right questions, even though he has no answers. ¡°The
evolutionary relationships between actin, MreB, and ParM
remain unclear, as they are similarly divergent from each other,¡±
he drones in one place, and ¡°The interrelatedness of these
spiraled structures remains unclear,¡± in another.
The rest of his references of evolution only assume it. He
has convergent evolution (read: simultaneous miracles) happening all
over the place. He personifies nature in the previous quote:
¡°nature¡¯s optimal solution to a problem.¡± Now that we know who the
Darwin Party¡¯s goddess is – Tinkerbell – we wish him luck getting optimal solutions from her.
Tinkerbell¡¯s technique is to zap organisms with mutations using her
magic wand. But she flitters about from place to place with no
goal in mind, only hoping that the bullets she fires into the machinery
will make things run better. You know the game is rigged when two
separate organisms arrive at the same optimal solution. Calling it
convergent evolution will not fool the perceptive viewers of this magic
kingdom; they know somebody is behind the scenes controlling the
show. For this reason, we have to give this story both
the Amazing and Dumb awards. Amazing for the bacteria, Dumb for
the human.